Running Title: Mechanism of action of ADC carrying pyrrolobenzodiazepine Corresponding author:

نویسندگان

  • Yong Ma
  • S Cyrus Khojasteh
  • Cornelis ECA Hop
  • Hans K Erickson
  • Andrew Polson
  • Thomas H Pillow
  • Shang-Fan Yu
  • Hong Wang
  • Peter S Dragovich
  • Donglu Zhang
چکیده

Drug Metabolism & Pharmacokinetics (YM, SCK, CECAH, DZ), Discovery Chemistry (PSD, THP), Translational Oncology (SY, AP), Protein Chemistry (HKE), Development Toxicology (HW), Genentech, South San Francisco, CA 94080, USA. This article has not been copyedited and formatted. The final version may differ from this version. DMD Fast Forward. Published on September 28, 2016 as DOI: 10.1124/dmd.116.073031

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

dynamic-clamp study of the role of Ih and GABAergic synaptic integration

Title: 1 The mechanism of ethanol action on midbrain dopaminergic neuron firing: a 2 dynamic-clamp study of the role of Ih and GABAergic synaptic integration 3 4 Authors: Takashi Tateno and Hugh P. C. Robinson 5 Affiliation: 6 1) PRESTO, Japan Science and Technology Agency, 4-1-8 Honcho Kawaguchi, Saitama, Japan. 7 2) Department of Physiology, Development and Neuroscience, Downing Street, Cambr...

متن کامل

Chemical Structure and Concentration of Intratumor Catabolites Determine Efficacy of Antibody Drug Conjugates

Despite recent technological advances in quantifying antibody drug conjugate (ADC) species, such as total antibody, conjugated antibody, conjugated drug, and payload drug in circulation, the correlation of their exposures with the efficacy of ADC outcomes in vivo remains challenging. Here, the chemical structures and concentrations of intratumor catabolites were investigated to better understan...

متن کامل

Intracellular Released Payload Influences Potency and Bystander-Killing Effects of Antibody-Drug Conjugates in Preclinical Models.

Antibody-drug conjugates (ADC) comprise targeting antibodies armed with potent small-molecule payloads. ADCs demonstrate specific cell killing in clinic, but the basis of their antitumor activity is not fully understood. In this study, we investigated the degree to which payload release predicts ADC activity in vitro and in vivo ADCs were generated to target different receptors on the anaplasti...

متن کامل

Preclinical Evaluation of MEDI0641, a Pyrrolobenzodiazepine-Conjugated Antibody-Drug Conjugate Targeting 5T4.

Antibody-drug conjugates (ADC) are used to selectively deliver cytotoxic agents to tumors and have the potential for increased clinical benefit to cancer patients. 5T4 is an oncofetal antigen overexpressed on the cell surface in many carcinomas on both bulk tumor cells as well as cancer stem cells (CSC), has very limited normal tissue expression, and can internalize when bound by an antibody. A...

متن کامل

Title: Scraping through the Ice: Uncovering the Role of Trpm8 in Cold Transduction Running Title: Trpm8, a Cold Sensor

Title: Scraping through the ice: Uncovering the role of TRPM8 in cold transduction Running title: TRPM8, a cold sensor Authors: Daniel D. McCoy, Wendy M. Knowlton and David D. McKemy* Author Affiliations: Neurobiology, University of Southern California, Los Angeles, California 90089, USA *Corresponding author information: David D. McKemy 3641 Watt Way, HNB 228 University of Southern California ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2016